Science aboard

Affordable and fast omics services and consulting solutions for researchers from project design to data interpretation

ABOUT BPC

Established in 2022, BPC is a life science company offering a range of experimental and bioinformatics-focused omics services and consulting solutions to support your R&D projects at all stages, from experimental design and sample processing to data analysis, interpretation and reporting. 

 

BPC’s portfolio includes single-cell, spatial and bulk transcriptomics, next-generation sequencing, RNA analysis, (spatial) proteomics, extracellular vesicles and bioinformatics. We are also proud to provide scientific consulting and editing services from a diverse panel of leaders from academia and industry, who cover a range of human disease backgrounds and preclinical models, including large animal models. Discover the full range of our services here.

 

BPC is headquartered in Houston, Texas with European offices located in Lausanne, Switzerland. The company was founded by Dr. Prabhu Mathiyalagan, having the first employee starting work in December 2022.


SERVICES

OMICS SERVICES

  • Single-cell and single-nucleus transcriptomics (scRNA-seq, snRNA-seq)
  • Spatial transcriptomics
  • Single-cell DNA methylation 
  • Long noncoding RNA sequencing (lncRNA) and lncRNA discovery (lncRNA-seq)
  • Single cell full-length transcriptome sequencing for RNA isoforms (SMART-seq)
  • Chromatin-IP (ChIP-seq)
  • RNA-IP (RIP-seq)
  • PRO-seq (RNA Polymerase, enhancer RNA active sites)
  • Direct RNA sequencing by nanopore for RNA modifications (epitranscriptomics)
  • Exosomes and extracellular vesicles RNA (transcriptomics) and protein (proteomics)
  • BIOINFORMATICS Analysis of omics datasets

CONSULTING SERVICES

  • Experimental and bioinformatics pipeline design and application 
  • ASO, siRNA design for RNA-based drug discovery and gene knockdown
  • Interpretation for biology and therapeutic discovery of large omics datasets
  • Omics-based discovery and therapeutics pathway directions
  • Rapid preparation of data and figures for grants and manuscripts editing for improved success
  • Interpretation of publicly available Omics datasets for therapeutics
  • Small and large animal study design
  • Scientific editing to optimize clarity, accuracy and impact of a diverse range of scientific communications for successful manuscript publications and grants

OUR TEAM

Prabhu Mathiyalagan

CEO

Originally from Tamil Nadu, India, Prabhu graduated as a PhD Scientist from Baker Heart and Diabetes Institute (Monash University) in Melbourne and after completing postdoctoral research in the United States, he settled down with his family in Switzerland. Prabhu’s scientific career encompasses over 15 years in various academic and project management R&D roles in prestigious institutions such as Mount Sinai Hospital (USA), New York University (USA), Monash University (Australia) and ground-breaking startup Haya Therapeutics (Switzerland). Prabhu published more than 20 journal articles (including >10 high-impact articles as the lead author with over 3000 research citations), served as an editor and guest editor for various journals, including American Heart Association, Frontiers and MDPI publishers.

CUSTOMERS & ACCOMPLISHMENTS

Some of our past and present clients include 


  • Mount Sinai Hospital, NY, USA
  • The Ohio State University, OH, USA
  • University of Zurich, Switzerland
  • Temple University, PA, USA
  • University of Arkansas, AR, USA
  • University of Derby, England
  • Nottingham Trent University, England

Testimonials

Jane Faber

6 months ago

Jane Faber

Professor Hina Chaudhry

Professor Hina Chaudhry

Director of Cardiovascular Regenerative Medicine

Mount Sinai Hospital, New York, USA

Working with Dr. Mathiyalagan and his company Benthos is allowing us to delve deeper into mechanisms of regenerative biology. It has greatly added to our ability to understand important molecular signaling pathways regulating various regenerative processes, and we hope to work together on many projects in the future! Benthos provides outstanding service in a timely manner, and at lower cost than many other similar services, with the bioinformatics expertise of Dr. Mathiyalagan, one of the most knowledgeable scientists I have encountered in this field!




We collaborate with Benthos Prime Central for our single nucleus transcriptomics project, and their insights and support has been invaluable. Their team provided us with expert guidance on sample preparation, data acquisition, and analysis, allowing us to achieve results with high precision. They were not only thorough in their technical support but also responsive to our specific needs throughout the project. Thanks to their help, we successfully generated a comprehensive transcriptomic profile that has greatly advanced our understanding of our study. I highly recommend Benthos Prime Central for their dedication to quality and experience in the field of single nucleus transcriptomics.

Dr. Esmaa Bouhamida

University of Ferrara, Italy & Mount Sinai Hospital

New York, USA

Jane Faber

6 months ago

Jane Faber

Professor Hina Chaudhry

Dr. Joanna Filipowska

Arthur Riggs Diabetes & Metabolism Research Institute

California, USA

I highly recommend Benthos Prime Central and Prabhu for their exceptional services. From start to finish, very attentive, professional, going above and beyond to meet my needs. Prabhu’s expertise and knowledge are extremely valuable in the process. Benthos’ commitment to customer satisfaction truly sets them apart, making my experience not just positive, but outstanding. Highly recommended, will definitely use their services again.

We got single mouse oocytes analysed by RNA sequencing and WGBS and are highly satisfied with the service offered by Benthos Prime Central. The sequencing was of good quality and the contact and exchanges with the company efficient. Our analysis using the preprocessed count matrix provided by Benthos yielded results comparable to those from our routine in-lab pipeline. Supplied QC plots and metadata were helpful and greatly supported our analysis.

Professor Isabelle Mansuy

University Zürich and ETH Zürich

Zurich, Switzerland

OUR RESEARCH CITATIONS

Compilation of publications referencing Benthos Prime Central alongside prominent keywords highlighting our expert services

Blood pressure, Epigenomics, RNA-seq, ATAC-seq, Omics, Machine Learning in omics, noncoding genome, enhancers, tissue-specific gene expression


https://www.sciencedirect.com/science/article/pii/S2211124723013633

https://www.biorxiv.org/content/10.1101/2022.04.19.488795v1

ChIP-seq, Chromatin modification and remodeling, GWAS, SNPs, Regulatory genome, noncoding genome, RNA-seq, ATAC-seq, Human diseases



https://www.medrxiv.org/content/10.1101/2023.12.07.23299084v1.full

Single nucleus RNA-seq (snRNA-seq) in tissues, Single Cell Transcriptomics, Omics, Cardiovascular, Heart regeneration, Cell cycle regulation, Transgenic mouse model, Bulk RNA-seq, Human transcriptomics


https://www.biorxiv.org/content/10.1101/2024.03.01.583057v1

Exosomes and extracellular vesicles (EV) transcriptomics, omics, AAV gene delivery, gene therapy, heart disease, EV proteomics, Noncoding RNA, miRNA


https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.122.063759?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Noncoding RNA, chromatin regulation by RNA, RNA-binding proteins (RBP), epitranscriptomics (m6A), RNA biology, Human diseases, RNA-based therapeutics


https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1069427/full

ATAC-seq, Functional genomics, SNPs, Genomics, Transcriptomics, Hypertension, Disease Omics, Machine Learning, Artificial Intelligence, Bioinformatics


https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.123.22538?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

RESEARCH CITATIONS FROM OUR TEAM 

Cardiac Epitranscriptomics, RNA Biology, Transcriptomics, siRNA, RNA Therapeutics, Heart disease, AAV gene therapy, RNA modifications, m6A RNA methylation, RNA immunoprecipitation, cardiomyocyte contractility, mouse models



https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.033794?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Angiogenesis, Extracellular Vesicles, Exosomes, Transcriptomics, Proteomics, Noncoding RNA, microRNA (miRNA), Exosomal RNA, Ischemia, Stem Cells, Peripheral Artery Disease, Stem Cell Exosomes


https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.310557?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Long Noncoding RNA (lncRNA), RNA Therapeutics, ASO/siRNA, ChIP-seq, PRC2 (Polycomb Repressive Complex), Epigenetics, Histone Modifications, EZH2, Cardiovascular, Chromatin Remodeling, Histone Modification


https://academic.oup.com/nar/article/42/2/790/1022502?login=false

ChIP-seq, Functional Genomics, Transcriptomics, Epigenomics, Small Molecule Inhibitor, HDAC inhibitor, Histone Acetylation/Deacetylation, Disease Omics



https://www.nature.com/articles/s41392-021-00546-y

DNA Methylation, Methylome, Disease Epigenetics, Pulmonary Arterial Hypertension, Transcriptomics, Epigenomics, Genome Architecture, Inter- and Intra- Chromosomal Interactions, Chromatin Accessibility


https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.047978?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

RNA Therapeutics, RNA Immunoprecipitation (RIP), Chromatin-interacting RNAs, RNA Methylation, Epitranscriptomics, DNA Methylation, MeCP2, Sex Differences, Sex-Specific Transcriptomics, Sex-Specific Epigenetics, Long Noncoding RNA


https://www.cell.com/iscience/fulltext/S2589-0042(19)30214-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004219302147%3Fshowall%3Dtrue

Tissue Engineering, Noncoding RNA, RNA Therpaeutics, MicroRNA (miRNA), Extracellular Vesicles, Exosomes, Stem Cells, Transcriptomics, Stem Cell Delivery


https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.312420?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Extracellular Vesicles Therapeutics, Exosomes Therapeutics, EV Therapeutics, Gene Therapy, Clinical Research, EV Omics


https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.120.049254?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Diabetes, Metabolic Disorders, Pancreas, Type I Diabetes, Type II Diabetes, Epigenetics, Cellular Reprogramming, Endocrine


https://www.liebertpub.com/doi/10.1089/ars.2014.6103?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

Epigenetics, Cardiovascular Disease, Cellular Reprogramming, Long Noncoding RNA, MicroRNA, RNA Therapeutics,


https://www.jmcc-online.com/article/S0022-2828(19)30019-7/abstract

Human Disease Epigenetics, Histone Modifications, Genes and Promoter, Transcription, Gene Expression, Transcriptomics


https://www.tandfonline.com/doi/abs/10.4161/cc.9.3.10612

Long Noncoding RNAs, Chromatin Remodeling, Histone Modifications, ChIP-seq


https://www.tandfonline.com/doi/full/10.4161/epi.26405

OUR RESEARCH CITATIONS

Compilation of publications referencing Benthos Prime Central alongside prominent keywords highlighting our expert services

Chromatin Modifications, Chromatin Remodeling, HDAC Inhibitors, Small Molecule Inhibitors, Heart Disease


https://academic.oup.com/cardiovascres/article/103/1/7/411922?login=false

Gene Therapy, RNA Therapy, MicroRNA Therapy, Exosomes Therapy, miRNA Delivery, RNA Delivery


https://link.springer.com/protocol/10.1007/978-1-4939-6588-5_9

Extracellular Vesicles and Exosomes Methods, EV Isolation, SV Standardiation, EV Therapy, Gene Therapy


https://www.nature.com/articles/nmeth.4185

Contact Us!

This is a paragraph. Writing in paragraphs lets visitors find what they are looking for quickly and easily.

Learn more

This is a paragraph. Writing in paragraphs lets visitors find what they are looking for quickly and easily.

This is a paragraph. Writing in paragraphs lets visitors find what they are looking for quickly and easily.

Learn more

This is a paragraph. Writing in paragraphs lets visitors find what they are looking for quickly and easily.

Learn more

This is a paragraph. Writing in paragraphs lets visitors find what they are looking for quickly and easily.

Learn more

Jane Faber, New York

This is a paragraph. Writing in paragraphs lets visitors find what they are looking for quickly and easily.

This is a paragraph. Writing in paragraphs lets visitors find what they are looking for quickly and easily.

Jane Faber, New York

Jane Faber, New York

Phone

+41 792097495

+1 7132987730

 

E-mail

mathip@mybenthos.com

 

Our Address

Houston, TX 77096 USA

 

Schedule

Mon-Fri 9am – 5pm CT

Fill in the details and we will contact you as soon as possible

Contact Us

Share by: